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Simmitecan free base

Name: Simmitecan free base
Brand: TargetMol
SKU: T202854
Rating: 4.5 (1 reviews)

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Catalog No. T202854Cas No. 951290-31-6

Alias 34Q82842ZK

Simmitecan is a potent topoisomerase I inhibitor and a promising water-soluble prodrug of chimmitecan. It exhibits significant antitumor activity both in vitro and in vivo by inhibiting topoisomerase I.

Simmitecan free base

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Catalog No. T202854Alias 34Q82842ZKCas No. 951290-31-6

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Simmitecan is a potent topoisomerase I inhibitor and a promising water-soluble prodrug of chimmitecan. It exhibits significant antitumor activity both in vitro and in vivo by inhibiting topoisomerase I.
Alias	34Q82842ZK

Chemical Properties

Molecular Weight	598.69
Formula	C₃₄H₃₈N₄O₆
Cas No.	951290-31-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc