Shopping Cart
- Remove All
Your shopping cart is currently empty
SN-398
😃Good
Catalog No. T88266Cas No. 124623-00-3
SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.
SN-398
😃Good
Catalog No. T88266Cas No. 124623-00-3
SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM). SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells. |
| Molecular Weight | 410.40 |
| Formula | C22H19FN2O5 |
| Cas No. | 124623-00-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy SN-398 | purchase SN-398 | SN-398 cost | order SN-398 | SN-398 chemical structure | SN-398 formula | SN-398 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.