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SNT-207858

Name: SNT-207858
Brand: TargetMol
SKU: T12946
Rating: 4.5 (1 reviews)

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Catalog No. T12946Cas No. 1104080-42-3

SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

SNT-207858

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Catalog No. T12946Cas No. 1104080-42-3

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
Targets&IC50	MC-4 receptor (function):11 nM , MC-4 receptor (binding):22 nM
In vitro	SNT207858 demonstrates binding to the MC-4 receptor at an affinity of 22 nM, exhibiting significant specificity with a 170-fold greater selectivity when compared to MC-3, and a 40-fold increased selectivity relative to MC-5.
In vivo	In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days).

Chemical Properties

Molecular Weight	689.54
Formula	C₃₂H₄₅Cl₄N₅O₃
Cas No.	1104080-42-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

SNT-207858SNT207858SNT 207858function, MC-4 receptorbinding, MC-4 receptor