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SPH3127

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Catalog No. T62618Cas No. 1399849-02-5

SPH3127 (DRI 18) is a potent, orally active, novel direct renin inhibitor with IC50 values of 0.4 nM for recombinant human-renin and 0.45 nM for human plasma renin activity. SPH3127 has an anti-hypertensive effect and can be used to study hypertension.

SPH3127

SPH3127

😃Good
Catalog No. T62618Cas No. 1399849-02-5
SPH3127 (DRI 18) is a potent, orally active, novel direct renin inhibitor with IC50 values of 0.4 nM for recombinant human-renin and 0.45 nM for human plasma renin activity. SPH3127 has an anti-hypertensive effect and can be used to study hypertension.
Pack SizePriceAvailabilityQuantity
25 mg$2,1408-10 weeks
50 mg$2,7858-10 weeks
100 mg$3,5208-10 weeks
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Product Introduction

Bioactivity
Description
SPH3127 (DRI 18) is a potent, orally active, novel direct renin inhibitor with IC50 values of 0.4 nM for recombinant human-renin and 0.45 nM for human plasma renin activity. SPH3127 has an anti-hypertensive effect and can be used to study hypertension.
Chemical Properties
Molecular Weight444.53
FormulaC22H32N6O4
Cas No.1399849-02-5
Storage & Solubility Information
StorageShipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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