QCan inhibitors be used for cell experiments?
AYes, our inhibitors can be used for cell/in vitro experiments. However, some compounds may not have literature supporting their use in cell experiments. In such cases, we cannot guarantee efficacy.
QDoes prolonged sonication affect the compound structure?
AIt is recommended to sonicate at a lower frequency
QHow to use compounds in animal experiments? How to determine dosage and administrative routes?
AThe usage of the same compound may vary for different animal models and disease models. It is recommended to decide the usage based on the experimental purpose and refer to literatures.
Common administration routes include intraperitoneal injection, oral gavage, etc. Due to the first-pass effect, compounds that can be administered orally may also be suitable for intraperitoneal injection, but those suitable for intraperitoneal injection may not necessarily be suitable for oral gavage. Dosages for different species can be converted based on tables provided on our official website. It is best to refer to specific literatures for dosages in a particular animal species.
Our compounds can be used in both cell and animal experiments, but some compounds may not have literature supporting their use in animal experiments. In such cases, we cannot guarantee efficacy.
QHow do you ensure the quality and purity of compounds?
AThe structure of compounds is confirmed through HNMR and purity is verified through HPLC or LCMS, with most compounds having a purity of over 98%. Each batch comes with a Certificate of Analysis (COA), and testing reports are also displayed on our official website.
QCan Tween-80 be used instead of Tween-20?
ATween-20 is not recommended. Tween-80 has better tolerance and has been used as a tool to assess the behavioral effects of experimental drugs and toxins without significant side effects.
Reference: Castro CA, Hogan JB, Benson KA, Shehata CW, Landauer MR. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6.