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Tanaproget

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Catalog No. T16985Cas No. 304853-42-7
Alias NSP-989

Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),

Tanaproget

Tanaproget

😃Good
Catalog No. T16985Alias NSP-989Cas No. 304853-42-7
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),
Pack SizePriceAvailabilityQuantity
2 mg$1125 days
5 mg$1975 days
10 mg$2975 days
25 mg$6155 days
1 mL x 10 mM (in DMSO)$2175 days
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Product Introduction

Bioactivity
Description
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),
In vitro
In T47D cells, TNPR induces alkaline phosphatase activity with an EC(50) value of 0.1 nm, comparable with potent steroidal progestins such as medroxyprogesterone acetate (MPA) and trimegestone (TMG), albeit with a reduced efficacy ( approximately 60%). In a mammalian two-hybrid assay to measure PR agonist-induced interaction between steroid receptor co-activator-1 and PR, TNPR showed similar potency (EC(50) value of 0.02 nm) and efficacy to MPA and TMG [1].
In vivo
TNPR effectively down-regulated MMP expression in vitro and induced a significant reduction of lesions in mice with disease established by tissues from endometriosis patients. The maximum concentration (C(max)) of tanaproget occurred approximately 2 to 3 h after administration. The elimination half-life (t(1/2)) ranged from 12 to 30 h, and the oral clearance was approximately 70 L/h. The pharmacokinetics of tanaproget was not noticeably altered with a high-fat meal [2][3].
AliasNSP-989
Chemical Properties
Molecular Weight297.38
FormulaC16H15N3OS
Cas No.304853-42-7
Relative Density.1.26 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (168.14 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3627 mL16.8135 mL33.6270 mL168.1350 mL
5 mM0.6725 mL3.3627 mL6.7254 mL33.6270 mL
10 mM0.3363 mL1.6814 mL3.3627 mL16.8135 mL
20 mM0.1681 mL0.8407 mL1.6814 mL8.4068 mL
50 mM0.0673 mL0.3363 mL0.6725 mL3.3627 mL
100 mM0.0336 mL0.1681 mL0.3363 mL1.6814 mL

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