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TAS-114

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Purity:99.76%

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COA

TAS-114

Catalog No. T13089Cas No. 1198221-21-4

TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU.

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Pack Size	Price	Availability	Quantity
2 mg	$299	In Stock

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Product Introduction

Bioactivity

Description	TAS-114 is an orally active dual inhibitor of dUTPase and dihydropyrimidine dehydrogenase (DPD). TAS-114 targets the intercellular metabolism of 5-FU to enhance antitumor activity and modulates catabolic pathways to improve the systemic availability of 5-FU.
In vitro	In HeLa, NUGC-4, NCI-H441, HT-29, CFPAC-1, and MCF-7 cell lines, TAS-114 (72 hours; 1 μM, 3 μM, and 10 μM) can significantly enhance the cytotoxicity of FdUrd and 5-FU against various cancer cell lines in a dose-dependent manner[1].
In vivo	In BALB/c nude mice with MX-1 human breast cancer xenografts, TAS-114 (37.5 to 1200 mg/kg/day; orally; daily; 1-14 days) can decrease the tolerable doses of Capecitabine (539 mg/kg/day) in a dose-dependent manner in mice[1].
Alias	TAS114, TAS 114

Chemical Properties

Molecular Weight	451.54
Formula	C21H29N3O6S
Cas No.	1198221-21-4

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (177.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2146 mL	11.0732 mL	22.1464 mL	110.7322 mL
5 mM	0.4429 mL	2.2146 mL	4.4293 mL	22.1464 mL
10 mM	0.2215 mL	1.1073 mL	2.2146 mL	11.0732 mL
20 mM	0.1107 mL	0.5537 mL	1.1073 mL	5.5366 mL
50 mM	0.0443 mL	0.2215 mL	0.4429 mL	2.2146 mL
100 mM	0.0221 mL	0.1107 mL	0.2215 mL	1.1073 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAS-114