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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide that inhibits Elk-1 by mimicking its DEF domain and disrupting its function. It effectively blocks Elk-1 phosphorylation and its subsequent nuclear translocation, without affecting the activation of ERK or MSK1. This compound serves as a valuable tool for investigating Elk-1's involvement in the development of neuronal plasticity [1]. |
In vitro | Elk-1 phosphorylation at Ser383/389 serves a dual role, instigating Elk-1's translocation to the nucleus and activating SRE-mediated gene expression [1]. |
In vivo | TAT-DEF-Elk-1 TFA, administered via intraperitoneal injection at a dosage of 1mg/kg daily for 14 days, exhibits antidepressant effects in mice, reducing immobility comparably to established reference antidepressants such as fluoxetine and desipramine (DMI) [1]. |
Alias | TDE TFA |
Cas No. |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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