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tetranor-PGDM

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Catalog No. T38306Cas No. 70803-91-7

Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.

tetranor-PGDM

tetranor-PGDM

😃Good
Catalog No. T38306Cas No. 70803-91-7
Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.
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25 μg$396 35 days
50 μg$765 35 days
100 μg$1,440 35 days
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Product Introduction

Bioactivity
Description
Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.
Chemical Properties
Molecular Weight328.361
FormulaC16H24O7
Cas No.70803-91-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 50 mg/mL (152.27 mM), Sonication is recommended.
DMSO: 50 mg/mL (152.27 mM), Sonication is recommended.
Ethanol: 50 mg/mL (152.27 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (3.05 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMF/DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.0454 mL15.2271 mL30.4543 mL152.2714 mL
DMF/DMSO/Ethanol
1mg5mg10mg50mg
5 mM0.6091 mL3.0454 mL6.0909 mL30.4543 mL
10 mM0.3045 mL1.5227 mL3.0454 mL15.2271 mL
20 mM0.1523 mL0.7614 mL1.5227 mL7.6136 mL
50 mM0.0609 mL0.3045 mL0.6091 mL3.0454 mL
100 mM0.0305 mL0.1523 mL0.3045 mL1.5227 mL

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