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tetranor-PGDM

Name: tetranor-PGDM
Brand: TargetMol
SKU: T38306
Rating: 4.5 (1 reviews)

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Catalog No. T38306Cas No. 70803-91-7

Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.

tetranor-PGDM

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Catalog No. T38306Cas No. 70803-91-7

Pack Size	Price	Availability
25 μg	Inquiry	35 days
50 μg	Inquiry	35 days
100 μg	Inquiry	35 days

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	328.361
Formula	C₁₆H₂₄O₇
Cas No.	70803-91-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMF: 50 mg/mL (152.27 mM), Sonication is recommended.

DMSO: 50 mg/mL (152.27 mM), Sonication is recommended.

Ethanol: 50 mg/mL (152.27 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (3.05 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0454 mL	15.2271 mL	30.4543 mL	152.2714 mL

DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.6091 mL	3.0454 mL	6.0909 mL	30.4543 mL
10 mM	0.3045 mL	1.5227 mL	3.0454 mL	15.2271 mL
20 mM	0.1523 mL	0.7614 mL	1.5227 mL	7.6136 mL
50 mM	0.0609 mL	0.3045 mL	0.6091 mL	3.0454 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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