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Thalidomide-NH-PEG2-C2-NH-Boc

Name: Thalidomide-NH-PEG2-C2-NH-Boc
Brand: TargetMol
SKU: T39524
Price: 34 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T39524Cas No. 2097509-40-3

Alias Thalidomide-NH-PEG2-C2-NH-Boc

Thalidomide-NH-PEG2-C2-NH-Boc, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon-targeting Thalidomide ligand with a PEG linker for the synthesis of dBRD9 (compound 6). This selective BRD9 probe PROTAC degrader is utilized in researching BAF complex biology.

Thalidomide-NH-PEG2-C2-NH-Boc

Catalog No. T39524Alias Thalidomide-NH-PEG2-C2-NH-BocCas No. 2097509-40-3

Pack Size	Price	Availability	Quantity
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	Thalidomide-NH-PEG2-C2-NH-Boc, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon-targeting Thalidomide ligand with a PEG linker for the synthesis of dBRD9 (compound 6). This selective BRD9 probe PROTAC degrader is utilized in researching BAF complex biology.
In vitro	dBRD9, at concentrations ranging from 0 to 1 μM, significantly inhibits cell proliferation, demonstrating effectiveness that is 10 to 100 times greater than that of non-degrading probes[1].
Alias	Thalidomide-NH-PEG2-C2-NH-Boc

Chemical Properties

Molecular Weight	504.53
Formula	C₂₄H₃₂N₄O₈
Cas No.	2097509-40-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thalidomide NH PEG2 C2 NH BocThalidomide-NH-PEG-2-C2-NH-BocThalidomideNHPEG2C2NHBoc