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Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739.
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500 mg | Inquiry | Backorder |
Description | Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739. |
In vitro | XZ739, functioning as a CRBN-dependent PROTAC BCL-XL degrader, exhibits a potent activity with a DC50 of 2.5 nM in MOLT-4 cells, post a 16-hour exposure. Additionally, it promotes caspase-mediated apoptosis, leading to cell death[1]. |
Alias | Thalidomide-NH-PEG4-Ms |
Molecular Weight | 527.55 |
Formula | C22H29N3O10S |
Cas No. | 2140807-24-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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