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Description | Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology. |
In vitro | PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets the specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [2]. |
Alias | Thalidomide-O-C5-NH2 hydrochloride |
Molecular Weight | 395.84 |
Formula | C18H22ClN3O5 |
Cas No. | 2419145-66-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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