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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Theliatinib (Xiliertinib) tartrate is a potent and highly selective EGFR inhibitor, displaying ATP-competitive and orally active properties. It exhibits promising efficacy with a K_i of 0.05 nM and an IC_50 of 3 nM for EGFR, alongside a specific IC_50 of 22 nM against the EGFR T790M/L858R mutant. Notably, Theliatinib demonstrates over 50-fold selectivity for EGFR compared to other kinases, underscoring its targeted action in inhibiting EGFR. |
Alias | Xiliertinib tartrate, HMPL-309 tartrate, Xiliertinib tartrate ; HMPL-309 tartrate |
Molecular Weight | 592.6 |
Formula | C29H32N6O8 |
Cas No. | 2413487-72-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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