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Thiol-PEG6-alcohol is a PEG-based linker for PROTACs, joining two essential ligands for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Description | Thiol-PEG6-alcohol is a PEG-based linker for PROTACs, joining two essential ligands for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, while the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Alias | HS-PEG6-OH |
Molecular Weight | 298.4 |
Formula | C12H26O6S |
Cas No. | 194425-46-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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