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THK5351

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THK5351

Catalog No. T13151LCas No. 1707147-26-9

THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.

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Pack Size	Price	Availability	Quantity
1 mg	$199	In Stock
1 mL x 10 mM (in DMSO)	$489	In Stock

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Product Introduction

Bioactivity

Description	THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.
In vitro	The autoradiographic images of brain sections demonstrate that THK5351 selectively binds to neurofibrillary tangles and exhibits a higher signal-to-background ratio compared to THK5117[1].
In vivo	THK5351 exhibited favorable pharmacokinetics and no defluorination in mice[1].

Chemical Properties

Molecular Weight	327.35
Formula	C18H18FN3O2
Cas No.	1707147-26-9

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (91.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0548 mL	15.2742 mL	30.5483 mL	152.7417 mL
5 mM	0.6110 mL	3.0548 mL	6.1097 mL	30.5483 mL
10 mM	0.3055 mL	1.5274 mL	3.0548 mL	15.2742 mL
20 mM	0.1527 mL	0.7637 mL	1.5274 mL	7.6371 mL
50 mM	0.0611 mL	0.3055 mL	0.6110 mL	3.0548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

THK 5351THK5351THK-5351