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Timolol hemimaleate

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Timolol hemimaleate

Catalog No. T87530Cas No. 33305-95-2

Timolol hemimaleate ((S)-L-714,465; MK 950), a β-blocker, is formulated for both systemic and topical use. It is commonly applied topically to decrease intraocular pressure in cases of open-angle glaucoma and ocular hypertension. Additionally, it is utilized in research for the treatment of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation. Moreover, Timolol has been recognized for its cardioprotective effects [1] [2].

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Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	Timolol hemimaleate ((S)-L-714,465; MK 950), a β-blocker, is formulated for both systemic and topical use. It is commonly applied topically to decrease intraocular pressure in cases of open-angle glaucoma and ocular hypertension. Additionally, it is utilized in research for the treatment of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation. Moreover, Timolol has been recognized for its cardioprotective effects [1] [2].
In vitro	Timolol hemimaleate significantly prevents increased lipid peroxidation in the hearts of diabetic rats, induces a balanced ratio between oxidative stress and antioxidant defense, and provides important cardioprotection against diabetes-induced ERS and associated apoptotic effects [3].
In vivo	Timolol hemimaleate exhibits cardioprotective effects in diabetic rats by inhibiting the ERS response [3]. Animal model: 3-month-old male Wistar rats [3]. Dosage: 5 mg/kg. Administration: 5 mg/kg daily for 12 weeks. Result: Demonstrated cardioprotective effects.

Chemical Properties

Molecular Weight	374.45
Formula	C13H24N4O3S.1/2C4H4O4
Cas No.	33305-95-2

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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