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TST1N-224

Catalog No. T89489Cas No. 50566-97-7

TST1N-224 is an effective VraRC inhibitor that disrupts the formation of the VraRC-DNA complex (IC50=60.2 μM). It interferes with the binding of VraRC to its homologous DNA through a rapid binding mechanism (KD=23.4 μM) and primarily interacts with the DNA binding domain helices α9 and α10 of VraR. TST1N-224 inhibits the growth of Staphylococcus aureus (SA; MIC>126 μM), methicillin-resistant Staphylococcus aureus (MRSA; MIC>126 μM), and vancomycin-intermediate Staphylococcus aureus (VISA; MIC=63 μM). As an antimicrobial, TST1N-224 significantly enhances the sensitivity of VISA to vancomycin and methicillin.

TST1N-224

TST1N-224

Catalog No. T89489Cas No. 50566-97-7
TST1N-224 is an effective VraRC inhibitor that disrupts the formation of the VraRC-DNA complex (IC50=60.2 μM). It interferes with the binding of VraRC to its homologous DNA through a rapid binding mechanism (KD=23.4 μM) and primarily interacts with the DNA binding domain helices α9 and α10 of VraR. TST1N-224 inhibits the growth of Staphylococcus aureus (SA; MIC>126 μM), methicillin-resistant Staphylococcus aureus (MRSA; MIC>126 μM), and vancomycin-intermediate Staphylococcus aureus (VISA; MIC=63 μM). As an antimicrobial, TST1N-224 significantly enhances the sensitivity of VISA to vancomycin and methicillin.
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Product Introduction

Bioactivity
Description
TST1N-224 is an effective VraRC inhibitor that disrupts the formation of the VraRC-DNA complex (IC50=60.2 μM). It interferes with the binding of VraRC to its homologous DNA through a rapid binding mechanism (KD=23.4 μM) and primarily interacts with the DNA binding domain helices α9 and α10 of VraR. TST1N-224 inhibits the growth of Staphylococcus aureus (SA; MIC>126 μM), methicillin-resistant Staphylococcus aureus (MRSA; MIC>126 μM), and vancomycin-intermediate Staphylococcus aureus (VISA; MIC=63 μM). As an antimicrobial, TST1N-224 significantly enhances the sensitivity of VISA to vancomycin and methicillin.
Chemical Properties
Molecular Weight460.65
FormulaC10H20O8S6
Cas No.50566-97-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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