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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cell lung, renal, prostate, and breast cancers [1]. |
In vitro | Tubulin polymerization-IN-2 (compound 2b) exhibits potent anti-cancer properties, effectively targeting epidermal carcinoma and breast carcinoma with IC50 values of 2.3 μM (KB) and 2.2 μM (BT-549), respectively [1]. At 0.342 μM over 24 hours, it disrupts DNA synthesis or repair, causes S phase arrest in MCF-7 cells, and induces apoptosis by reducing Bax, APAF-1, and caspase-3 expression while increasing BCL-2 mRNA levels [1]. It also significantly inhibits β-tubulin polymerization with a K_i value of 0.09 μM at concentrations of 0.01 to 10 μM over one hour [1]. |
Molecular Weight | 314.29 |
Formula | C17H12F2N2O2 |
Cas No. | 2873399-22-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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