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UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent.
Description | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent. |
In vitro | UBE2T/FANCL-IN-1 (CU2) effectively prevents GST-FANCLRING ubiquitylation at 100 μM and significantly reduces FANCD2 ubiquitylation mediated by HU and Cisplatin (10 μM) at 500 μM over 6, 12, and 24 hours. Additionally, 250 μM UBE2T/FANCL-IN-1 combined with 15 μM carboplatin markedly inhibits cell proliferation, resulting in less than 50% confluence after 8 days[1]. |
Alias | UBE2T/FANCL-IN-1 |
Molecular Weight | 357.506 |
Formula | C19H31N7 |
Cas No. | 1359415-02-3 |
Relative Density. | 1.28 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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