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UBE2T/FANCL-IN-1
🥰Excellent
Catalog No. T38765Cas No. 1359415-02-3
Alias UBE2T/FANCL-IN-1
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent.
UBE2T/FANCL-IN-1
🥰Excellent
Catalog No. T38765Alias UBE2T/FANCL-IN-1Cas No. 1359415-02-3
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent.
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Product Introduction
Bioactivity
Chemical Properties
| Description | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, significantly enhancing cellular sensitivity to Carboplatin, a DNA cross-linking agent. |
| In vitro | UBE2T/FANCL-IN-1 (CU2) effectively prevents GST-FANCLRING ubiquitylation at 100 μM and significantly reduces FANCD2 ubiquitylation mediated by HU and Cisplatin (10 μM) at 500 μM over 6, 12, and 24 hours. Additionally, 250 μM UBE2T/FANCL-IN-1 combined with 15 μM carboplatin markedly inhibits cell proliferation, resulting in less than 50% confluence after 8 days[1]. |
| Alias | UBE2T/FANCL-IN-1 |
| Molecular Weight | 357.506 |
| Formula | C19H31N7 |
| Cas No. | 1359415-02-3 |
| Relative Density. | 1.28 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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