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Umbralisib tosylate

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Catalog No. T72465Cas No. 1532533-72-4
Alias TGR-1202 tosylate ; RP5264 tosylate, TGR-1202 tosylate, RP5264 tosylate

Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.

Umbralisib tosylate
Other Forms of Umbralisib tosylate:

Umbralisib tosylate

😃Good
Catalog No. T72465Alias TGR-1202 tosylate ; RP5264 tosylate, TGR-1202 tosylate, RP5264 tosylateCas No. 1532533-72-4
Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.
AliasTGR-1202 tosylate ; RP5264 tosylate, TGR-1202 tosylate, RP5264 tosylate
Chemical Properties
Molecular Weight743.75
FormulaC38H32F3N5O6S
Cas No.1532533-72-4
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

TGR-1202 tosylate ; RP 5264 TosylateUmbralisib TosylateRP5264 TosylateTGR-1202 tosylate ; RP5264 TosylateTGR 1202 TosylateTGR-1202 TosylateTGR1202 TosylateRP-5264 TosylateRP 5264 TosylateTGR-1202 tosylate ; RP-5264 Tosylate
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