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UNC8153

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Catalog No. T88389Cas No. 2929304-60-7

UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.

UNC8153

UNC8153

😃Good
Catalog No. T88389Cas No. 2929304-60-7
UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.
Chemical Properties
Molecular Weight583.68
FormulaC33H37N5O5
Cas No.2929304-60-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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