Shopping Cart

Remove All
Your shopping cart is currently empty

VCP/p97 inhibitor-1

Name: VCP/p97 inhibitor-1
Brand: TargetMol
SKU: T40255
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T40255Cas No. 2630950-38-6

Alias VCP/p97 inhibitor-1

VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

VCP/p97 inhibitor-1

😃Good

Catalog No. T40255Alias VCP/p97 inhibitor-1Cas No. 2630950-38-6

Pack Size	Price	Availability	Quantity
25 mg	$1,520	Backorder

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
Targets&IC50	VCP/p97:54.7 nM
In vitro	VCP/p97 inhibitor-1 (compound 17), administered at 3-fold serial dilutions with a maximum concentration of 10 μM for 72 hours, demonstrates an anti-proliferative effect on A549 and RPMI8226 cells, with IC50 values of 2.9 μM and 0.86 μM, respectively, as shown in the Cell Viability Assay[1].
Alias	VCP/p97 inhibitor-1

Chemical Properties

Molecular Weight	491.37
Formula	C₂₄H₂₆BN₅O₄S
Cas No.	2630950-38-6
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VCP/p97 inhibitor 1VCP/p-97 inhibitor-1VCP/p97 inhibitor1