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VHL Ligand 14
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Catalog No. T87617Cas No. 2010986-87-3
VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1].
VHL Ligand 14
😃Good
Catalog No. T87617Cas No. 2010986-87-3
VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1]. |
| In vitro | VHL Ligand 14 (5-10 μM) stabilizes the ER degrader in PROTAC, facilitating the degradation of ER [1]. Using Western Blot Analysis [1] with the MCF-7 cell line at a concentration of 5-10 μM over a 4-hour incubation period, it was found to inhibit the degradation of the ER ligand. |
| Molecular Weight | 486.63 |
| Formula | C25H34N4O4S |
| Cas No. | 2010986-87-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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