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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,088 | Backorder | |
10 mg | $1,744 | Backorder |
Description | Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for studying transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and breast carcinoma[1][2]. |
In vitro | Vinflunine (0.01-10 μM; 45 min) rapidly alters endothelial cell morphology, causing cells to retract and become rounded[2]. Additionally, within 1 hour at the same concentration range, it disrupts the formation of capillary-like structures and inhibits endothelial cell motility, achieving an inhibition concentration (IC50) of 0.71 μM[2]. Furthermore, over a period of 1 to 72 hours, Vinflunine (0.001-10 μM) effectively suppresses the proliferation of endothelial cells in vitro[2]. |
In vivo | Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells[2].Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner[2]. Animal Model: Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells[2] |
Molecular Weight | 967.03 |
Formula | C49H60F2N4O14 |
Cas No. | 194468-36-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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