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VU0364572
Catalog No. T88352Cas No. 1240514-87-7
VU0364572 TFA is a selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential by preventing memory impairment and reducing neuropathology associated with Alzheimer's disease. Additionally, VU0364572 TFA is orally active and permeates the central nervous system.
VU0364572
Catalog No. T88352Cas No. 1240514-87-7
VU0364572 TFA is a selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential by preventing memory impairment and reducing neuropathology associated with Alzheimer's disease. Additionally, VU0364572 TFA is orally active and permeates the central nervous system.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | VU0364572 TFA is a selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential by preventing memory impairment and reducing neuropathology associated with Alzheimer's disease. Additionally, VU0364572 TFA is orally active and permeates the central nervous system. |
| In vitro | VU0364572 (30 μM; 25 min) enhances the phosphorylation of KCNQ2, NR1, and MARCKS in striatal/NAc slices [2]. |
| In vivo | VU0364572 (10 mg/kg/day; oral; 4 months) TFA demonstrates neuroprotective effects in 5XFAD transgenic Alzheimer's mice. The half-life of VU0364572 is 45 minutes [1]. |
| Molecular Weight | 373.49 |
| Formula | C21H31N3O3 |
| Cas No. | 1240514-87-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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