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VU0364770 hydrochloride

Catalog No. T13317Cas No. 1414842-70-8

VU0364770 hydrochloride is a potent and selective mGlu4 positive allosteric modulator (PAM) (EC50s: 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively).

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Pack Size	Price	Availability
2 mg	$31	5 days
5 mg	$47	7-10 days
1 mL x 10 mM (in DMSO)	$118	7-10 days

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Product Introduction

Bioactivity

Description

VU0364770 hydrochloride is a potent and selective mGlu4 positive allosteric modulator (PAM) (EC50s: 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively).

Chemical Properties

Molecular Weight	269.13
Formula	C12H10Cl2N2O
Cas No.	1414842-70-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (371.57 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7157 mL	18.5784 mL	37.1568 mL	185.7838 mL
5 mM	0.7431 mL	3.7157 mL	7.4314 mL	37.1568 mL
10 mM	0.3716 mL	1.8578 mL	3.7157 mL	18.5784 mL
20 mM	0.1858 mL	0.9289 mL	1.8578 mL	9.2892 mL
50 mM	0.0743 mL	0.3716 mL	0.7431 mL	3.7157 mL
100 mM	0.0372 mL	0.1858 mL	0.3716 mL	1.8578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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