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WHI-P180 hydrochloride
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Catalog No. T61007Cas No. 153437-55-9
WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.
WHI-P180 hydrochloride
😃Good
Catalog No. T61007Cas No. 153437-55-9
WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor. |
| In vivo | WHI-P180 acts as an effective inhibitor of IgE-mediated mast cell responses. In CD-1 (BALB/c) mice, its elimination half-life is below 10 minutes across intravenous (i.v.), intraperitoneal (i.p.), and oral (p.o.) administrations. Systemic clearance rates for WHI-P180 are recorded at 6742 mL/h/kg in CD-1 mice and 8188 mL/h/kg in BALB/c mice. Importantly, administering two consecutive, non-toxic i.p. bolus doses of 25 mg/kg of WHI-P180 suppresses IgE/antigen-induced vascular hyperpermeability in a validated mouse model of passive cutaneous anaphylaxis. |
| Molecular Weight | 333.77 |
| Formula | C16H16ClN3O3 |
| Cas No. | 153437-55-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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