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YF-2 hydrochloride
🥰Excellent
Catalog No. T38711Cas No. 1312005-62-1
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
YF-2 hydrochloride
🥰Excellent
Catalog No. T38711Cas No. 1312005-62-1
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
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Product Introduction
Bioactivity
Chemical Properties
| Description | YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties. |
| Targets&IC50 | PCAF:29.04 μM (EC50), GCN5:49.31 μM (EC50), CBP:2.75 μM (EC50) |
| In vitro | YF-2, at concentrations ranging from 0.03 to 80 μM for 72 hours, effectively inhibits the proliferation of U251, CCRF-CEM, Hs578T, and NCI-ADR-RES cells[1]. |
| In vivo | YF-2 administered intraperitoneally at a dosage of 20 mg/kg two hours before or at 5 mg/kg thirty minutes before an electric shock, ameliorates the impairment in contextual memory observed in mice. However, at a dosage of 20 mg/kg without preceding electric shock, YF-2 does not influence contextual memory in mice [1]. |
| Molecular Weight | 467.31 |
| Formula | C20H23Cl2F3N2O3 |
| Cas No. | 1312005-62-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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