Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM. |
In vitro | ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity and demonstrates excellent selectivity compared with other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC 50 >50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC 50 =8 nM) and VEGFR2 tyrosine phosphorylation [1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM [2]. |
Molecular Weight | 375.4 |
Formula | C22H18FN3O2 |
CAS No. | 193001-14-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ZM323881 193001-14-8 ZM-323881 ZM 323881 inhibitor inhibit