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ZNL0325 is a covalent probe based on pyrazolo[1,2-a]pyrimidine that demonstrates an alternative binding mode for kinases, where the C3 position is reversed facing the ribose-binding pocket. ZNL0325 and its analogs feature an acrylamide side chain at the C3 position, capable of forming covalent bonds with various kinases possessing cysteine at the αD-1 position, including BTK, EGFR, BLK, and JAK3.
Pack Size | Price | Availability | Quantity |
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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | ZNL0325 is a covalent probe based on pyrazolo[1,2-a]pyrimidine that demonstrates an alternative binding mode for kinases, where the C3 position is reversed facing the ribose-binding pocket. ZNL0325 and its analogs feature an acrylamide side chain at the C3 position, capable of forming covalent bonds with various kinases possessing cysteine at the αD-1 position, including BTK, EGFR, BLK, and JAK3. |
Alias | ZNL-0325, ZNL 0325 |
Molecular Weight | 316.36 |
Formula | C15H20N6O2 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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