Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities, showing selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) and no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis. It mildly inhibits the growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL. Intravenous administration of actinopyrone A (30 μg/kg) increases coronary blood flow in dogs by 196.2%.