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ALDH1A3 Protein, Human, Recombinant (His)

Catalog No. TMPY-01899

ALDH1A3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 57 kDa and the accession number is A0A024RC95.

ALDH1A3 Protein, Human, Recombinant (His)

ALDH1A3 Protein, Human, Recombinant (His)

Catalog No. TMPY-01899
ALDH1A3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 57 kDa and the accession number is A0A024RC95.
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50 μg$6007-10 days
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
ALDH1A3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 57 kDa and the accession number is A0A024RC95.
Species
Human
Expression System
E. coli
TagN-His
Accession NumberP47895
Synonyms
RALDH3,MCOP8,ALDH6,ALDH1A6,aldehyde dehydrogenase 1 family, member A3
Construction
A DNA sequence encoding the human ALDH1A3 (NP_000684.2) (Ala 2-Pro 512) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met
Protein Purity
> 96 % as determined by SDS-PAGE
Molecular Weight57 kDa (predicted); 57 kDa (reducing conditions)
EndotoxinPlease contact us for more information.
FormulationSupplied as sterile PBS 7.4 10% glycerol 0.2% TWEEN20.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingShipping with blue ice.
Research Background
Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.

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