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Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μg | $275 | 7-10 days | |
100 μg | $539 | 7-10 days | |
1 mg | $3,520 | 7-10 days |
Biological Information | Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.5μg/mL. |
Description | BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 kDa and the accession number is C8C060. |
Species | Human,Mouse,Rat,Rhesus,Canine |
Expression System | E. coli |
Tag | Tag Free |
Accession Number | C8C060 |
Synonyms | bone morphogenetic protein 2 |
Construction | The mature form of Human / Mouse / Rat / rhesus / canine BMP2 (NP_001191.1) (Gln283-Arg396) was expressed with an initial Met. The mature form sequences of Human, Mouse, Rat, rhesus and canine BMP2 are identical. |
Protein Purity | > 95 % as determined by SDS-PAGE |
Molecular Weight | 13 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 3% CAN, 1% TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma. |
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