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BMP-7 Protein, Human, Recombinant
Catalog No. TMPJ-01473
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.
BMP-7 Protein, Human, Recombinant
Catalog No. TMPJ-01473
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg | $310 | Backorder | |
| 50 μg | $1,165 | Backorder | |
| 500 μg | $5,832 | Backorder |
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| Biological Activity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Recombinant Human Bone morphogenetic protein 7 is produced by our Mammalian expression system and the target gene encoding Ser293-His431 is expressed. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | P18075 |
| Synonyms | Osteogenic protein 1,OP-1,OP1,Eptotermin alfa,Bone morphogenetic protein 7,BMP7 |
| Amino Acid | Ser293-His431 |
| Construction | Ser293-His431 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Molecular Weight | 18-23 KDa (reducing condition) |
| Endotoxin | < 1 EU/μg by the LAL method. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM PB, 100 mM NaCl, 5% Mannitol, 0.05% Tween 80, pH7.5. |
| Stability & Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 6 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Shipping with blue ice. |
| Research Background | Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. |
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