Immobilized Claudin-4 Protein-VLP, Human, Recombinant (Flag) (Cat#TMPY-07140) at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin-4 Monoclonal antibody, Human IgG1, the EC50 is 10-30 ng/mL.

Claudin-4 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is O14493.

CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable in normal ovaries. Claudins form a large family of tight junction proteins that have essential roles in the control of paracellular ion flux and the maintenance of cell polarity. CLDN4 has been identified as a specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), a nontoxic molecule that may disrupt TJ barrier function and enhance cellular absorption. Claudin-4, encoding a protein for tight junction formation and function, is highly overexpressed in pancreatic ductal adenocarcinoma and is also associated with invasive adenocarcinomas arising in intraductal papillary mucinous neoplasms of the pancreas. Claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation. CLDN4 is a tight junction protein involved in blood-brain barrier integrity.