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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $320 | In Stock | |
100 μg | $547 | 7-10 days | |
200 μg | $935 | 7-10 days | |
500 μg | $1,890 | 7-10 days |
Biological Information | 1. The specific activity was determined to be>70 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
2. Immobilized EGF Protein, Human, Recombinant (ECD, hFc Tag) at 2 μg/mL (100 μL/well) can bind EGFR Protein, Human, Recombinant (aa 668-1210, His & GST Tag)in functional ELISA. |
Description | EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.1 kDa and the accession number is P00533-1. |
Species | Human |
Expression System | Baculovirus Insect Cells |
Tag | His, GST |
Accession Number | P00533-1 |
Synonyms | epidermal growth factor receptor,PIG61,ERBB1,NISBD2,ERBB,HER1,mENA |
Construction | The cytoplasmic domain (Met 668-Ala 1210) of Human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
Protein Purity | > 75 % as determined by SDS-PAGE ![]() |
Molecular Weight | 89.1 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. |
Research Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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