1. Immobilized EphA6 Protein, Human, Recombinant (His) (Cat#TMPY-07134) at 2 μg/mL (100 μL/well) can bind Ephrin A3 Protein, Human, Recombinant (hFc) (Cat#TMPY-01392), the EC50 is 20-60 ng/mL.
2. Loaded Ephrin A3 Protein, Human, Recombinant (hFc) (Cat#TMPY-01392) on proA Biosensor, can bind EphA6 Protein, Human, Recombinant (His) (Cat#TMPY-07134) with an affinity constant of 43.1 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).

EphA6 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9UF33.

≥ 90% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC.

Ephrin type-A receptor 6, also known as EphA6 or EHK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. In the vomeronasal system, Ephrin-A5/EphA6 interactions mediate attraction or adhesion rather than repulsion.