FGF-21 Protein, Human, Recombinant

Catalog No. TMPY-06935

FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.

FGF-21 Protein, Human, Recombinant

Catalog No. TMPY-06935

FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.

Pack Size	Price	Availability
50 μg	$245	In Stock
100 μg	$435	7-10 days
200 μg	$770	7-10 days
500 μg	$1,630	7-10 days

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COA User Guide of Recombinant Proteins

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Product Information

Biological Activity	Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.1-0.6 µg/mL in the presence of Recombinant Mouse Klotho beta.
Description	FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	NP_061986.1
Synonyms	UNQ3115 / PRO10196,fibroblast growth factor 21
Construction	A DNA sequence encoding the Human FGF21 (NP_061986.1) (His29-Ser209) was expressed. Predicted N terminal: Met
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Molecular Weight	19.55 kDa (predicted); 22.4 kDa (reducing conditions)
Endotoxin	< 10 EU/mg of the protein.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.