FGF-21 Protein, Human, Recombinant (His)

Catalog No. TMPY-01889

FGF-21 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.2 kDa and the accession number is A0A7U3L5M7.

FGF-21 Protein, Human, Recombinant (His)

Catalog No. TMPY-01889

FGF-21 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.2 kDa and the accession number is A0A7U3L5M7.

Pack Size	Price	Availability	Quantity
50 μg	$306	7-10 days
1 mg	$3,000	7-10 days

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Product Information

Biological Activity	Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.1-1 µg/mL in the presence of 2.5 µg/mL of rmKlotho β.
Description	FGF-21 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.2 kDa and the accession number is A0A7U3L5M7.
Species	Human
Expression System	E. coli
Tag	N-His
Accession Number	Q9NSA1
Synonyms	UNQ3115 / PRO10196,fibroblast growth factor 21
Construction	A DNA sequence encoding the mature form of human FGF21 (NP_061986.1) (His 29-Ser 209) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	20.2 kDa (predicted); 23 kDa (reducing conditions)
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from 50 mM Tris, 10% glycerol, 0.05% Brij 35, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.