GAS6 Protein, Human, Recombinant (His)

Catalog No. TMPY-04999

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.

GAS6 Protein, Human, Recombinant (His)

Catalog No. TMPY-04999

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50 μg	$510	7-10 days

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Product Information

Biological Activity	1. Loaded Anti-Human Gas6 mAb-Fc on Protein A Biosensor, can bind Human GAS6-His with an affinity constant of 5.45 nM as determined in BLI assay. _x000D_ 2. Immobilized Human AXL-His at 10μg/ml (100 μl/well) can bind Human GAS6-His: Biotinylated by NHS-biotin prior to testing. The ED50 of Recombinant Human GAS6-His is 0.04466 ug/ml.
Description	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
Accession Number	Q14393-2
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE.
Molecular Weight	72.7 KDa (Predicted), 80-90 KDa (Reducing conditions)