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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $600 | In Stock | |
1 mg | $3,910 | 7-10 days |
Biological Information | Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The ED50 for this effect is 3-10 μg/mL in the presence of 0.4ng/mL GMCSF. |
Description | GM-CSFR alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P15509-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | P15509-1 |
Synonyms | GM-CSF-R-α,colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage),CSF2RAY,CSF2RAX,GM-CSF Receptor α Protein,CSF2R,CSF2RY,CSF2RX,CDw116,GM-CSF-R-alpha,CD116,GMR,SMDP4,GMCSFR,colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
Construction | The extracellular domain (Met 1-Gly 320) of Human GM-CSFRα (P15509-1) was expressed with the C-terminal fused polyhistidine tag. |
Protein Purity | > 90 % as determined by SDS-PAGE |
Molecular Weight | 36 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. |
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