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HGF Protein, Canine, Recombinant

Catalog No. TMPY-00456

HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7.

HGF Protein, Canine, Recombinant

HGF Protein, Canine, Recombinant

Catalog No. TMPY-00456
HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7.
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50 μg438 €7-10 days
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Product Information

Biological Activity
Measured by its ability to neutralize TGF-beta mediated inhibition on Mv-1-Lu cell proliferation. The ED50 for this effect is typically 1-4 ng/mL.
Description
HGF Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.9 kDa and the accession number is Q867B7.
Species
Canine
Expression System
HEK293 Cells
TagTag Free
Accession NumberQ867B7
Synonyms
scatter factor),hepatocyte growth factor (hepapoietin A
Construction
A DNA sequence encoding the canine HGF (NP_001002964.1) (Met1-Ser730) was expressed. Predicted N terminal: Gln 32
Protein Purity
> 95 % as determined by SDS-PAGE.
Molecular Weight79.9 kDa (predicted)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by mesenchymal cells as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility and matrix invasion give it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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