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HGFR/c-Met Protein, Human, Recombinant (His), AF488-Labeled is expressed in HEK293 Cells. The accession number is P08581-1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $539 | Backorder | |
100 μg | $1,730 | Backorder |
Biological Activity | 1. Flow cytometric analysis of anti-c-MET CAR expression. 293 cells were lentivirally transduced with anti-c-MET CAR. Flow cytometric analysis was performed with a negative control protein and HGFR/c-Met Protein, Human, Recombinant (His), AF488-Labeled (Cat#TMPY-07026), respectively. Non-transduced 293 cells were used as a control (left). 2. Binding activity of AF 488-conjugated c-MET protein to PBMC cells. PBMC cells were stained with anti-CD3 antibody and HGFR/c-Met Protein, Human, Recombinant (His), AF488-Labeled (Cat#TMPY-07026) and detected by flow cytometry. PBMC cells stained with anti-CD3 antibody were used as a control (left). |
Description | HGFR/c-Met Protein, Human, Recombinant (His), AF488-Labeled is expressed in HEK293 Cells. The accession number is P08581-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | P08581-1 |
Synonyms | RCCP2,HGFR,DFNB97,DA11,c-Met,AUTS9 |
Construction | A DNA sequence encoding the Human MET (NP_000236.2) (Met1-Thr932) was expressed with a polyhistidine tag at the C-terminus. The protein is site-specifically labeled with AF 488 (Excitation Max. = 495 nm, Emission Max. = 519 nm). |
Protein Purity | ≥ 90% as determined by SDS-PAGE. |
Molecular Weight | 105.1 kDa (predicted) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | This product is Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
Reconstitution | Please refer to the lot-specific COA. |
Stability & Storage | Twelve months from date of receipt at -20℃ to -70℃ in lyophilized form and 3 months at -70℃ under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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