Immobilized TROP-2 Protein, Human, Recombinant (His) (Cat#TMPY-01262) at 2 μg/mL (100 μL/well) can bind IGF2R Protein, Human, Recombinant (hFc) (Cat#TMPY-07125), with a linear range of 0.16-4.0 μg/mL.

IGF2R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P11717.

Human

HEK293 Cells

MPRI,MPR300,MPR1,MPR 300,M6P-R,M6P/IGF2R,IGF2R,CI-MPR,CIMPR,CI-M6PR,CD222

A DNA sequence encoding the Human Igf2r (P11717) (Met1-Asp1365) was expressed with the Fc region of human IgG1 at the C-terminus.

≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

Please refer to the lot-specific COA.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth, survival, migration and differentiation. The type 2 IGF receptor (IGF2R) modulates circulating and tissue levels of IGF2 by targeting it to lysosomes for degradation. The extracytoplasmic region of IGF2R has three binding sites: one for IGF2 in domain 11 and two for Man-6-P in domains 3, 5 and 9. Binding between IGF2 and IGF2R induces the lysosomal degradation of IGF2. IGF2R serves to clear IGF2 from the circulation or degrade excess circulating IGF2. Soluble IGF2R can affect the size of some organs exclusively by reducing the biological activity of IGF2.