IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)

Catalog No. TMPY-05338

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is Q13651.

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)

Catalog No. TMPY-05338

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is Q13651.

Pack Size	Price	Availability
100 μg	$451	In Stock
200 μg	$798	7-10 days
500 μg	$1,690	7-10 days

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COA User Guide of Recombinant Proteins

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Product Information

Biological Activity	Measured by its ability to inhibit IL-10 dependent proliferation of MC/9 mouse mast cells. Approximately 0.04-0.2 μg/mL of IL-10Rα will inhibit 50% of the biological response induced by 10 ng/mL of recombinant human IL-10.
Description	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is Q13651.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q13651
Synonyms	interleukin 10 receptor, α,interleukin 10 receptor, alpha,IL-10R1,IL10R,HIL-10R,CDW210A,CD210a,CD210
Construction	A DNA sequence encoding the human IL10RA (NP_001549.2) (Met1-Asn235) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: His 22
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	25.8 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other, not protein-coding have been found for this gene. CD210 belongs to the type II cytokine receptor family. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. CD210 is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with IL10RA include Inflammatory Bowel Disease 28, Autosomal Recessive, and Inflammatory Bowel Disease 28.