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IL-13 Protein, Cynomolgus, Recombinant

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COA

IL-13 Protein, Cynomolgus, Recombinant

Catalog No. TMPY-00982

IL-13 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.3 kDa and the accession number is Q0PW92.

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Pack Size	Price	Availability
20 μg	$228	In Stock
100 μg	$447	7-10 days
200 μg	$791	7-10 days
500 μg	$1,670	7-10 days

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Biological Description

Biological Information	Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 2-8 ng/mL.
Description	IL-13 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.3 kDa and the accession number is Q0PW92.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	Q0PW92
Synonyms	interleukin 13
Construction	Cynomolgus (Macaca fascicularis) IL13 (ABG75889.1) (Met 1-Asn 132) precursor
Protein Purity	> 85 % as determined by SDS-PAGE
Molecular Weight	12.3 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and diseases. Also, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody are more importantly implicated as a central mediator of immunoregulatory processes in various cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy