IL-1 beta/IL-1F2 Protein, Canine, Recombinant

Catalog No. TMPY-02568

IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292.

IL-1 beta/IL-1F2 Protein, Canine, Recombinant

Catalog No. TMPY-02568

IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292.

Pack Size	Price	Availability
20 μg	$177	In Stock
100 μg	$498	7-10 days
200 μg	$850	7-10 days
500 μg	$1,720	7-10 days

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COA User Guide of Recombinant Proteins

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Information

Biological Activity	1. Measured by its ability to bind human IL1R1 in a functional ELISA. 2. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.2-1ng/mL.
Description	IL-1 beta/IL-1F2 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q28292.
Species	Canine
Expression System	E. coli
Tag	Tag Free
Accession Number	Q28292
Synonyms	interleukin 1, β,interleukin 1, beta,IL-1 β
Construction	A DNA sequence encoding the mature form of canine IL1B (Q28292) (Ala 115-Ser 266) was expressed, with an initial Met at the N-terminus. Predicted N terminal: Met
Protein Purity	> 96 % as determined by SDS-PAGE.
Molecular Weight	17.6 kDa (predicted); 17 kDa (reducing conditions)
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 0.3M NaCl, pH 6. 5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy