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IL-6 Protein, Rat, Recombinant

Catalog No. TMPY-03298

IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.

IL-6 Protein, Rat, Recombinant

IL-6 Protein, Rat, Recombinant

Catalog No. TMPY-03298
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
Pack SizePriceAvailabilityQuantity
20 μg$177In Stock
100 μg$4477-10 days
200 μg$7937-10 days
500 μg$2,6207-10 days
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Product Information

Biological Activity
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 1-6 ng/ml.
IL-6 Protein, Rat, Recombinant
Description
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
Species
Rat
Expression System
E. coli
TagTag Free
Accession NumberA6KJN3
Synonyms
interleukin 6
Construction
A DNA sequence encoding the rat IL6 (NP_036721.1)(Phe25-Thr211) was expressed and purified with an initial Met. Predicted N terminal: Met
Protein Purity
> 85 % as determined by SDS-PAGE
IL-6 Protein, Rat, Recombinant
Molecular Weight21.9 kDa (predicted); 22 kDa (reducing condition, due to glycosylation)
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 40% acetonitrile, 0.1% TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Please read the User Guide of Recombinant Proteins for more specific information.