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IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μg | $177 | In Stock | |
100 μg | $447 | 7-10 days | |
200 μg | $793 | 7-10 days | |
500 μg | $2,620 | 7-10 days |
Biological Activity | Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 1-6 ng/ml. |
Description | IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3. |
Species | Rat |
Expression System | E. coli |
Tag | Tag Free |
Accession Number | A6KJN3 |
Synonyms | interleukin 6 |
Construction | A DNA sequence encoding the rat IL6 (NP_036721.1)(Phe25-Thr211) was expressed and purified with an initial Met. Predicted N terminal: Met |
Protein Purity | > 85 % as determined by SDS-PAGE |
Molecular Weight | 21.9 kDa (predicted); 22 kDa (reducing condition, due to glycosylation) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 40% acetonitrile, 0.1% TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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