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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $320 | In Stock | |
100 μg | $567 | 7-10 days | |
200 μg | $1,000 | 7-10 days | |
500 μg | $2,120 | 7-10 days |
Biological Information | Loaded Human ILT3 alpha Protein, His Tag on AR2G Biosensor, can bind Rhesus Angiopoietin-like 7 Protein, His Tag with an affinity constant of 68.94nM as determined in BLI assay (Routinely tested). |
Description | IL-T3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is Q8NHJ6. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | Q8NHJ6 |
Synonyms | CD85K,leukocyte immunoglobulin like receptor B4,ILT-3,LIR5,ILT3,LIR-5 |
Construction | The Human LILRB4 (NP_001265357.2) (Met1-Glu259) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ![]() ![]() |
Molecular Weight | 27.7 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the recruitment of SHP-1. LILRB4 is associated with the pathological processes of various inflammatory diseases. The LILRB4 is a central inhibitory receptor in Uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface. |
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