KIR2DL4 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-03651

KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.

KIR2DL4 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-03651

KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.
Species	Human
Expression System	CHO Cells
Tag	C-hFc
Accession Number	ADY38409.1
Synonyms	KIR-2DL4,KIR2DL4,KIR-103AS,KIR103AS,KIR103,KIR,killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4,G9P,CD158D
Construction	A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Trp 24
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	51.3 kDa (predicted); 62, 34 and 32 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.